Volume 26, Issue 1 (5-2013)                   3 2013, 26(1): 145-153 | Back to browse issues page

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Preventive effect of hydroalcoholic extract of Carthamus tinctorius petal in appearance of type 1-diabetes mellitus in adult male rats. 3. 2013; 26 (1) :145-153
URL: http://ibs.org.ir/article-1-135-en.html
Abstract:   (2811 Views)
Diabetes is a metabolic disorder characterised by hyperglycemia resulting from defects in insulin secretion, insulin action or both. <em>Carthamus tinctorius</em> (Compositae) has been used in Iranian traditional medicine in the treatment of diabetes.&amp;nbsp; In this study the blood glucose lowering effect of hydroalcoholic extract of <em>Carthamus tinctorius</em> petals was investigated in male Wistar rats. In this research 18 male white Wistar rats, with body weights of 180 &amp;ndash; 220 g were randomly allocated into three groups with six rats per group: group1, nondiabetic control; group2, diabetic control; group 3, prevention group. In order to induce diabetes, alloxan was administered as a single dose( 120 mgkg-1 BW), intraperitoneally.&amp;nbsp; In 2 and 3 groups to induce diabetes, alloxan was administered as a single dose( 120 mgkg<sup>-1</sup> BW), intraperitoneally. At the initial and the end of 2 and 6 weeks of experimental period, rats were fasted for 16h, and then fasting blood samples were collected in tubes with heparin for estimation of blood glucose and others factors levels.&amp;nbsp; Blood was collected from the orbital sinus. The results indicated significant reduction in serum glucose level in the group 3 (P&amp;lt;0.05). Histological studies of the pancreas of this animals, demonstrated this results. This results showed that the hydroalcoholic extract of <em>Carthamus tinctorius</em> effect on preventive of diabetes. The effect of this extract can be due to the presence of flavonoides and their antioxidant effects.
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Type of Study: Research |
Received: 2016/12/25 | Published: 2013/05/15

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