Volume 26, Issue 1 (5-2013)                   3 2013, 26(1): 52-60 | Back to browse issues page

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Cloning and expression of a scFv from an anti human plasminogen monoclonal antibody. 3. 2013; 26 (1) :52-60
URL: http://ibs.org.ir/article-1-125-en.html
Abstract:   (2314 Views)
Angiogenesis is the formation of new blood vessels from existing ones. New blood vessels provide the cells with metabolic requirements. Angiogenesis plays a pivotal role in many physiological and pathological phenomena. Proteinease especially plasmin is critical in degrading of matrix metalloproteinase releasing and activating different growth factor from it. Angiogenesis initiate by the activation of plasminogen on the cell surface. Our previous finding indicates that an anti human plasminogen monoclonal antibody could inhibit the angiogenesis. According to importance of this antibody, we tried to make the scfv of this antibody. SDS-PAGE and immunobloting analysis and ELISA confirmed the expression and immunological activity of the scFv. 
Full-Text [PDF 262 kb]   (488 Downloads)    
Type of Study: Research |
Received: 2016/12/25 | Published: 2013/05/15

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